Gene

tenm4

ID

ZDB-GENE-990714-20

Name

teneurin transmembrane protein 4

Symbol

tenm4 Nomenclature History

Previous Names

tenm4
nrg1
odz4

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have cell adhesion molecule binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in axon guidance. Predicted to localize to several cellular components, including neuron projection; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in essential tremor 5. Is expressed in several structures, including brain; midbrain hindbrain boundary neural rod; neural tube; optic vesicle; and retina. Orthologous to human TENM4 (teneurin transmembrane protein 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Hor et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tenm4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
essential tremor 5	Alliance	Essential tremor, hereditary, 5	616736

Associated With tenm4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR009471	Teneurin intracellular, N-terminal
Domain	IPR022385	Rhs repeat-associated core
Domain	IPR028916	Tox-GHH domain
Family	IPR051216	Teneurin domain-containing protein
Homologous_superfamily	IPR008969	Carboxypeptidase-like, regulatory domain superfamily
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Repeat	IPR006530	YD repeat
Repeat	IPR031325	RHS repeat

Domain Details Per Protein

Protein	Length	Carboxypeptidase-like, regulatory domain superfamily	EGF-like domain	RHS repeat	Rhs repeat-associated core	Six-bladed beta-propeller, TolB-like	Teneurin domain-containing protein	Teneurin intracellular, N-terminal	Tox-GHH domain	YD repeat
UniProtKB:A0A0R4ICV6 InterPro	2831
UniProtKB:A0A8M3ASI0 InterPro	2832
UniProtKB:A0A8M3APL5 InterPro	2807
UniProtKB:Q9W7R3 InterPro	2824
UniProtKB:A0A2R8QIZ5 InterPro	2840
UniProtKB:A0A0R4IN22 InterPro	2824
UniProtKB:A0A8M3AIB4 InterPro	2833
UniProtKB:A0A8M3AIB8 InterPro	2791
UniProtKB:A0A8M3B0T4 InterPro	2767
UniProtKB:A0A2R8RZ80 InterPro	2798

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tenm4-201 (1) Ensembl	Ensembl	534 nt	Select Tool
mRNA	tenm4-202 (1) Ensembl	Ensembl	12,435 nt	Select Tool ZFIN BLAST
mRNA	tenm4-203 (1) Ensembl	Ensembl	12,414 nt	Select Tool ZFIN BLAST
mRNA	tenm4-204 (1) Ensembl	Ensembl	9,523 nt	Select Tool
mRNA	tenm4-205 (1) Ensembl	Ensembl	12,537 nt	Select Tool ZFIN BLAST
mRNA	tenm4-206 (1) Ensembl	Ensembl	12,336 nt	Select Tool ZFIN BLAST
mRNA	tenm4-207 (1) Ensembl	Ensembl	12,462 nt	Select Tool ZFIN BLAST
mRNA	tenm4-208 (1) Ensembl	Ensembl	12,318 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations